PIONEER: Generating whole-proteome human interactome using deep learning

PIONEER is a deep learning-based framework that predicts partner-specific protein interfaces using a maximal amount of available information from both protein structures and sequences. In this browser, you can explore various information of protein interactions (search by UniProts or Gene Names), and you can also submit unresolved protein interactions to predict protein interfaces.

Visualize Interactions

Using the drop-down menu, pick 1 of the 3 options you would like to use to view the respective visualization. Next, enter in the corresponding Uniprot ID(s) or gene name(s) and press 'Visualize' to see the demonstration. If you don't know the Uniprot ID, go to www.uniprot.org. To see an example, click one of the 'Example' options at the bottom.

Search by:

Disease Name:

Example interaction Example protein Example disease
Submit a Job

To submit a job, enter a pair(s) of Uniprot IDs, each as a separate line, in the first box. Or upload a file (.excel or .csv) from your computer using the second box. If you don't know the Uniprot ID, go to wwww.uniprot.org. To see an example, click example at the bottom and enter your email to receive the results.

Enter a list of interactions:
Or upload a file:
Enter email:
Example 1 Example 2
Retrieve Results

Once your job is processed, you will receive an email with the job ID. Enter that job ID here to view the results.